Neosquamous Epithelium after Ablation

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Purpose: The goal of this study is to compare the morphological and functional aspects of the neosquamous epithelium (NSE) after ablative therapy for dysplastic Barrett’s esophagus (BE) to that of native squamous epithelium in normal controls as well as gastroesophageal reflux disease (GERD), non-Barrett’s Esophagus (BE) subjects.

Participants:  Patients aged 18-80 presenting at the Gl Endoscopy Clinic at UNC-Chapel Hill for elective upper endoscopy who:

  • will undergo radiofrequency ablation for Barrett’s esophagus or follow-up of radiofrequency ablation
  • are diagnosed with GERD (gastroesophageal reflux disease), or
  • have normal esophageal mucosa and are undergoing endoscopy for other indications.

Procedures (methods):  Esophageal biopsies for research purposes and questionnaire regarding the duration and frequency of reflux symptoms.  Subjects in the pre-ablation group may be followed during scheduled follow-up visits and can participate in an impedance-pH test to assess acid reflux.

Sponsors and Collaborators: American Society for Gastrointestinal Endoscopy

Principal Investigator: Dr. Nicholas Shaheen

Research Coordinator: Susie Bream